Summary

Levothyroxine is a synthetically produced form of thyroxine, a major endogenous hormone secreted by the thyroid gland.[F4633] Also known as L-thyroxine or the brand name product Synthroid, levothyroxine is used primarily to treat hypothyroidism, a condition where the thyroid gland is no longer able to produce sufficient quantities of the thyroid hormones T₄ (tetraiodothyronine or thyroxine) and T₃ (triiodothyronine or [DB00279]), resulting in diminished down-stream effects of these hormones. Without sufficient quantities of circulating thyroid hormones, symptoms of hypothyroidism begin to develop such as fatigue, increased heart rate, depression[A179620], dry skin and hair, muscle cramps, constipation, weig

Synonym type

Generic Names;Trade Names;Brand Mixtures;synonym

Synonym

(-)-Thyroxine 33'55'-Tetraiodo-L-thyronine 3355-Tetraiodo-L-thyronine 353'5'-TETRAIODO-L-thyronine 4-(4-Hydroxy-35-diiodophenoxy)-35-diiodo-L-phenylalanine Eltroxin Euthyrox L-T4 L-Thryoxin L-Thyroxine LT4 Laevothyroxinum Laevoxin Letter Levaxin Levo-t Levolet Levothroid Levothyrox Levothyroxin Levothyroxine Sodium Levoxine Levoxyl Liotrix (Levothyroxine + Liothyronine) Novothyrox O-(4-Hydroxy-35-diidophenyl)-35-diiodo-L-tyrosine O-(4-Hydroxy-35-diiodophenyl)-35-diiodo-L-tyrosine Oroxine Synthroid Synthroid Sodium T4 T4 levothyroxine THX Tetraiodothyronine Thyratabs Thyrax Thyreoideum Thyro-tabs Thyrolar (Levothyroxine + Liothyronine) Thyroxevan Thyroxin Thyroxinal Thyroxine iodine Unithroid

Xref

DrugBank: DB00451   PharmGKB: PA450221   TTD: D06RGG  

CAS

51-48-9

Formular

C15H11I4NO4

PubChem CID

CID 644282

UNII

Q51BO43MG4

ATC code

H03AA01

Drug Type

small molecule

Drug status

approved

Source

PharmGKB;Drugbank