Pathway
Toll-like Receptor Signaling Pathway
[ PW0000115 ]
- Summary
- Toll-like receptors (TLRs) are a critical part of the innate immune response, and are expressed on macrophages and dendritic cells. TLRs are pattern-recognition receptors, and recognize molecules derived from microbes. Once activated, TLRs result in activation of innate immunity by inducing production of proinflammatory cytokines and upregulation of costimulatory molecules TLR signaling pathways are separated into two groups: a MyD88-dependent pathway that leads to the production of proinflammatory cytokines with quick activation of NFkB and MAPK; and a MyD88-independent pathway associated with the induction of IFN-beta and IFN-inducible genes, and maturation of dendritic cells with slow activation of NFkB and MAPK.
- Source
- WikiPathways
- Pathway Ontology
- Toll-like receptor signaling pathway
Classification
Pathway
| Gene Symbol | Genomic Location | Type of Gene | Protein name | Ensembl RNA | Refseq RNA | Relation |
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